Six-day clinical trial finds integrative medicine program alters blood serum

Posted on Updated on


Source : University of California – San Diego

Summary : In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.

Image result

In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.

The findings, published in the September 9 issue of Scientific Reports, represent a rare attempt to use metabolic biomarkers to assess the reported health benefits of integrative medicine and holistic practices. Senior author of the study, which included researchers from multiple institutions, was Deepak Chopra, MD, clinical professor in the Department of Family Medicine and Public Health at University of California San Diego School of Medicine and a noted proponent of integrative medicine.

“It appears that a one-week Panchakarma program can significantly alter the metabolic profile of the person undergoing it,” said Chopra, whose foundation provided and managed funding for the study. “As part of our strategy to create a framework for whole systems biology research, our next step will be to correlate these changes with both gene expression and psychological health.”

Study co-author Paul J. Mills, PhD, professor of family medicine and public health and director of the Center of Excellence for Research and Training in Integrative Health, both at UC San Diego School of Medicine, noted that alternative and integrative medicine practices, such as meditation and Ayurveda, are extremely popular, but their effects on the human microbiome, genome and physiology are not fully understood. “Our program of research is dedicated to addressing these gaps in the literature.”

“The researchers looked at the effects of a Panchakarma-based Ayurvedic intervention on plasma metabolites in a controlled clinical trial,” said first author Christine Tara Peterson, PhD, a postdoctoral fellow at UC San Diego School of Medicine. “Panchakarma refers to a detoxification and rejuvenation protocol involving massage, herbal therapy and other procedures to help strengthen and rejuvenate the body.”

The study involved 119 healthy male and female participants between 30 and 80 years of age who stayed at the Chopra Center for Wellbeing in Carlsbad, Calif. Slightly more than half were assigned to the Panchakarma intervention (the Chopra Center’s Perfect Health program, which typically costs $2,865 for a six-day treatment). The remainder to a control group. Blood plasma analyses, using liquid chromatography and mass spectrometry, were taken before and after the six-day testing period.

The researchers found that in the Panchakarma group there was a measurable decrease in 12 specific cell-membrane chemicals (phosphatidylcholines) correlating with serum cholesterol and inversely related to Type 2 diabetes risk.

“These phospholipids exert broad effects on pathways related to inflammation and cholesterol metabolism,” said Peterson. “Plasma and serum levels of the metabolites of phosphatidylcholine are highly predictive of cardiovascular disease risk.”

Application of a less stringent measurement standard identified 57 additional metabolites differentially abundant between the two groups of participants. The authors suggested that given the very short duration of the trial, the serum profile changes were likely driven by the vegetarian diet component of Panchakarma. They said further studies were needed to more fully understand the processes and mechanisms involved.


Story Source:

The above post is reprinted from materials provided by University of California – San Diego. Note: Content may be edited for style and length.


Journal Reference:

  1. Christine Tara Peterson, Joseph Lucas, Lisa St. John-Williams, J. Will Thompson, M. Arthur Moseley, Sheila Patel, Scott N. Peterson, Valencia Porter, Eric E. Schadt, Paul J. Mills, Rudolph E. Tanzi, P. Murali Doraiswamy, Deepak Chopra. Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI). Scientific Reports, 2016; 6: 32609 DOI: 10.1038/srep32609

Source: 1

Advertisements

One thought on “Six-day clinical trial finds integrative medicine program alters blood serum

    […] Six-day clinical trial finds integrative medicine program alters blood serum – Senior author of the study, which included researchers from multiple institutions, was Deepak Chopra, MD, clinical professor in the Department of … but their effects on the human microbiome, genome and physiology are not fully understood. […]

Let us know what you think!

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s