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USFDA clears first test to detect genetic markers for antibiotic-resistant bacteria

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The U.S. Food and Drug Administration  cleared for marketing the Xpert Carba-R Assay, an infection control aid that tests patient specimens to detect specific genetic markers associated with bacteria that are resistant to Carbapenem antibiotics. Carbapenem antibiotics are widely used in hospitals to treat severe infections. These resistant organisms are commonly referred to as Carbapenem-resistant Enterobacteriaceae, or CRE, and have been reported in almost all states within the U.S.

“By using a specimen taken directly from a patient to test for the presence of genetic markers, hospitals can more quickly identify these dangerous bacteria resistant to certain antibiotics,” said Alberto Gutierrez, M.D., director of the FDA’s Office of In Vitro Diagnostics and Radiological Health within the Center for Devices and Radiological Health.

Current methods to identify colonization with CRE or other resistant organisms rely on growing bacteria from fecal material in cultures, which are then subjected to antimicrobial susceptibility testing to determine in vitro susceptibility to antimicrobial agents. Bacterial culture methods and susceptibility testing may take up to four days, and additional testing is often also required to confirm that carbapenemase, an enzyme that inactivates carbapenem antibiotics, is present. The Xpert Carba-R Assay tests specimens directly taken from patients, which are usually obtained by rectal swabs, for the presence of five different genetic markers that are associated with carbapenemase, the enzyme produced by CRE.

The Xpert Carba-R Assay is intended as an aid in infection control and can be used in conjunction with other clinical and laboratory findings. Although the Xpert Carba-R Assay tests for the most prevalent carbapenemase genes associated with resistance to carbapenem antibiotics, it does not detect the bacteria, carbapenemase activity or other possible non-enzymatic causes of carbapenem resistance. The Xpert Carba-R Assay tests only for genetic material.

The Xpert Carba-R Assay also does not detect all types of carbapenemase genes, and it is important to recover bacteria for accurately tracking the spread of carbapenem resistance. Labs should continue to perform standard bacterial culture in conjunction with the Xpert Carba-R Assay. In addition, concomitant cultures are necessary to recover organisms for epidemiological typing, antimicrobial susceptibility testing, and for confirmatory bacterial identification.

According to the Centers for Disease Control and Prevention, CRE infections most commonly occur in people with exposure to health care settings, like hospitals and long-term care facilities. Because of this, these types of infections often occur among patients who are receiving treatment for other serious conditions. Patients whose care requires devices like ventilators, urinary catheters, or intravenous catheters, and patients who are taking long courses of certain antibiotics are among those at risk for CRE infections.

CRE are usually resistant to many other antibiotics in addition to carbapenems, and several CRE outbreaks of these highly resistant bacteria have been reported in the U.S. When bacteria become resistant to carbapenems, few treatment options may remain. Some CRE bacteria have become resistant to almost all available antibiotics and present a significant public health threat.

The FDA’s decision to provide clearance was based on data from two clinical studies. A prospective study used rectal swabs from 755 patients in hospitals or long-term care facilities to compare results from the Xpert Carba-R Assay with results from reference cultures and automated real-time polymerase chain reaction (PCR) sequencing. A second study designed to test the clinical performance of the Xpert Carba-R Assay used 432 rectal swabs that were artificially prepared with specific concentrations of bacteria containing the genes detected by the test. The results of these studies demonstrated similar performance between the Xpert Carba-R Assay and culture method.
The Xpert Carba-R Assay is manufactured by Cepheid, located in Sunnyvale, Calif.

Source: 1, 2

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Centre for Traditional Medicines and Research has new plans to strengthen Siddha

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As part of promoting and developing the traditional Siddha treatment system worldwide, especially among the Tamil diaspora, the Chennai-based Centre for Traditional Medicines and Research (CTMR) has made scores of proposals to the Sri Lankan government on Siddha system of treatment as part of implementing various health projects in the northern Tamil Province of the island nation.

The Minister for Health for Northern Province, Dr. P. Sathyalingam had recently invited the director of CTMR Dr. T. Thirunarayanan to Sri Lanka to explain in detail the proposals he made to the Lankan government to strengthen the system there. The proposal sought support from the Indian government as well as the state government of Tamil Nadu. In the meeting, he discussed with various health officials, medical officers and hospital authorities who are following the traditional system of treatment there.

While sharing details about his visit to Sri Lanka, Dr Thirunarayanan said manufacture and supply of traditional drugs, especially Siddha medicines, is always a difficult problem there, and there occurs a long gap in the supply system. The quantum of medicines manufactured is very less and often inadequate to cater to the needs of the patients.

In a proposal to develop production and marketing of Siddha drugs, CTMR has suggested that maintenance of quality standard is of prime importance, and for that there should be a testing methodology which should be followed in the analytical process. A well equipped laboratory is essential to address issues like adulteration, misbranding, spurious, not-of-standard quality, etc. Besides, government should ensure availability of good raw materials.

To increase the availability of Siddha medicine in the island country, Dr. Thirunarayanan made a major suggestion that a government owned manufacturing unit with state-of-the-art facilities should be set up. The facilities should be in compliance with WHO-GMP standards. For the availability of raw drugs including herbs, medicinal plants, the government was advised to encourage founding herbal gardens at schools, colleges, homes, public parks, etc and planting of medicinal saplings as much as possible everywhere involving NGOs.

Further, he suggested to digitize the palm leaf manuscripts of Siddha available with traditional healers there and also with the libraries. CTMR will give training in the digitization of palm leaves. He said the government of Sri Lanka can approach the ministry of Ayush in India through ministry of external affairs for financial assistance to train the graduates in Siddha and to conduct continuous medical education programmes and skill development schemes.

For strengthening the potential and skill of traditional medicine practitioners in Sri Lanka, he said the Siddha practitioners in the Northern Province have to undergone specialized training in various treatment methods of Siddha like Varmam, Thokkanam, Kayakalpam, Balar maruthuvam, skin diseases, non-communicable diseases and mental health.

Source : Pharmabiz

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